Mu mirima ya bioharmaceticals nubushakashatsi bwa siyansi, gukuraho soliveni no kwibanda kubikoresho ni intambwe zingenzi muburyo bwo kugerageza no gukora umusaruro. Uburyo gakondo nko guhumeka kandi ikirerwa gikunze kubabazwa nimpamvu zidafite akamaro, gutakaza ibikoresho bifatika, kandi gukuraho Solvent Solvent. Laboratoire ikonjesha yumye, hamwe nibyiza byihariye byubushyuhe buke nubushyuhe hasi, byagaragaye nkibikoresho byiza cyane kuri ibi bikorwa. Muri bo,"Bondabari ku isonga mu guteza imbere ikoranabuhanga.
Ubumenyi bwihishe inyuma-kumisha: Ubushyuhe buke-bushyuhe
A Laboratoire Gukonjesha KumaKugera Gukuraho Solivent no Kwibanda kubintu Binyuze mubyiciro bitatu byingenzi:
Icyiciro cya mbere cyo gukonjesha:Ibikoresho birimo ibishoboka byihuta byihuse ku bushyuhe kuva kuri -40 ° C kugeza -80 ° C, gushiraho kristu ya kashi ikomeye.
Gukama byibanze (sublimation):Munsi ya vacuum (mubisanzwe munsi ya 10pa), kristu ya ice
Kruma kabiri (desosoption):Kwiyongera k'ubushyuhe bworoheje (20-40 ° C) byorohereza gusuzugura amazi yuzuye, bikaviramo ubushuhe bwa nyuma bwa 1% -5%.
Iyi nzira ikuraho ibyangiritse cyane kubintu byubushyuhe, kubungabunga imiterere ya proule ya poroteyine, enzymes, na vitamine. Byongeye kandi, irema imiterere ishyirwaho yorohereza rehydration yoroshye cyangwa porogaramu itaziguye.
Ibyiza byingenzi bya Laboratoire Gukonjesha Kuma
Ugereranije n'ibikoresho by'inganda, guhagarika guhagarika laboratoire bitanga igenzura ry'ibihe bidasanzwe n'inyungu zitunganya ibintu bito:
Kugenzura ubushyuhe busobanutse:Icyitegererezo cya "Bose"ZLGJ-12, kurugero, gukoresha compressor yatumijwe mu mahanga ikoranabuhanga, agera ku mutego wo mutego nka -80° C kugirango uhagarike vuba.
Ubuyobozi bw'ubwenge bwa vacuum:Sensors ishingiye ku buryo bwo hejuru ikomeza gukurikirana urwego rwa vacuum (≤5pa), hamwe no kubara mu rwego rwo kurinda kugira ngo birinde kugumana.
Gushyushya gradiet yo kwibanda:Ikoranabuhanga rishyuha cyane (nka "byombi".
Kurugero, mubigeragezo bya laboratoire yibinyabuzima birimo antibody guhagarika-gukama, uburyo bwo guhumeka gakondo bwatumye habaho gukusanya kwa poroteyi. Ibinyuranye, gukonjesha-gukama ku bushyuhe buke byabitswe mu 95% by'ibikorwa bya antibody, hamwe n'ifu yavuyemo bihamye byo kubika igihe kirekire.
Nka sosiyete ihindagurika mu mikino yo mu gihugu mu myaka 17, "Ibimera byoroheje byazamuye imikorere yo gukuraho Solvent binyuze mu guhanga udushya twikoranabuhanga.
1. Bitunganijwe neza amakuru ya sisitemu
Kumanura buri "byombi" bifite ibara rifite ibara rikoraho hamwe na data yo kubika amakuru (ashoboye kubika amajwi agera ku 100.000). Itanga ubushyuhe nyabwo-vacuum, Gushoboza abashakashatsi kugirango bamenye neza ingaruka zagabarikanirwa, kubuza ibibazo byumye cyangwa bisigaye.
2. Uburyo bwinshi bwo kurinda umutekano
Automatic Vacuum PUP gufunga niba ubushyuhe bwo mu mutego burenze -50 ° C kugirango wirinde kwangirika.
Ijwi ryumvikana kandi ryoroshye rifite ibikorwa byo kurinda byikora mugihe habaye kunanirwa no gutsindwa ubushyuhe budasanzwe.
Guhitamo imbaraga zangiza imbaraga zikomeza kugenzura sisitemu yiminota 20 mugihe cyo guhagarika imbaraga, kubuza ubushakashatsi.
3. Imikorere ya modular Kwagura
Hamwe na sisitemu yo kongera gutangaza gaze ya gaze, imyuka ya inert nka azote irashobora gutangizwa mucyumba cyumye kugirango wirinde reaction mugihe cyo kwibanda kuri ogisijeni-yunvikana (urugero: ethanol). Urugereko, rwakozwe mu ibyuma byisuku ridafite ishingiro hamwe nigishushanyo mbonera cyubutaka, kurandura ingaruka zambukiranya.
Laboratoire Gukonjesha Kumaba yavuye mu bikoresho byoroheje byo kuvoma mu buryo bunoze bwo kugenzura urupapuro. "Byombi"Zlgjurukurikirane, binyuze mu gishushanyo mbonera cy'ubwenge kandi cya modular ntabwo ari ugukuraho gusa neza ahubwo binafasha gukurikirana no guhitamo igihe cyo kwibanda. Kubashakashatsi bashyira imbere ubushishozi nibisubizo bihamye, ibi bikoresho bihinduka "umufasha usanzwe wungirije" muri laboratoire.
Igihe cya nyuma: Werurwe-13-2025
